The 22-250 Remington was introduced by Remington in 1965…but that's just part of its story. Based on the 250 Savage case necked down, it was wildcatted in several versions in the 1930s and remained a popular non-standard cartridge for the next 30 years. Remington's factory version was an overnight success! Today the 22-250 is the most popular long-range varmint cartridge, and probably the most popular 22 centerfire after the 223. All ammunition manufacturers offer it. Loads vary, but 50-grain loads run about 3800 feet per second. Heavier bullets are a bit slower, and with bullets of 40 to 45 grains it reaches or exceeds 4000 fps. It is a standard chambering for most manufacturers of bolt action and single-shot rifles, and is legendary for accuracy and performance on varmints. Bullets of 55 grains and below should be used for varmints; hunters wishing to use their 22-250s for deer should choose bullets of 60 grains and more intended for the purpose. — Craig Boddington

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